hsb-1 Heat shock factor-binding protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hsb-1
Official Full Name: Heat shock factor-binding protein 1
Primary source: WormBase:WBGene00002002
Locus tag: CELE_K08E7.2
See related: AllianceGenome:WB:WBGene00002002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in cellular heat acclimation. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including body wall musculature; intestine; pharynx; tail neurons; and vulval muscle. Orthologous to human HSBP1 (heat shock factor binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hsb-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (12566092..12567226, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08E7.3 (e-PCR)
- UniSTS:311479

K08E7.2 (e-PCR)
- UniSTS:321005

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular heat acclimation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Heat shock factor-binding protein 1

NP_001379159.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12566092..12567226 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392417.1 → NP_001379159.1 Heat shock factor-binding protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3B7

Conserved Domains (1) summary

pfam06825
Location:23 → 72

HSBP1; Heat shock factor binding protein 1