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ltah-1.1 Aminopeptidase ltah-1.1 [ Caenorhabditis elegans ]

Gene ID: 178176, updated on 9-Dec-2024

Summary

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Official Symbol
ltah-1.1
Official Full Name
Aminopeptidase ltah-1.1
Primary source
WormBase:WBGene00016589
Locus tag
CELE_C42C1.11
See related
AllianceGenome:WB:WBGene00016589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables aminopeptidase activity. Involved in peptide catabolic process. Located in cytosol. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ltah-1.1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (12279660..12281913)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mannose-1-phosphate guanylyltransferase catalytic subunit beta Neighboring gene Protein-lysine methyltransferase vkmt-1 Neighboring gene PAP2_C domain-containing protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Mitochondrial thiamine pyrophosphate carrier Neighboring gene Erlin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications. Mohandas N, et al. Biotechnol Adv, 2016 Mar-Apr. PMID 26597954
  2. Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases. Baset HA, et al. J Biol Chem, 1998 Oct 23. PMID 9774412
  3. The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function. Liu Z, et al. PLoS Genet, 2022 Jan. PMID 35089916, Free PMC Article
  4. AP-1 Recruits SMAP-1/SMAPs to the trans-Golgi Network to Promote Sorting in Polarized Epithelia. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34901019, Free PMC Article
  5. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Aminopeptidase ltah-1.1
NP_001023056.1
  • Partially confirmed by transcript evidence
NP_001023058.1
  • Partially confirmed by transcript evidence
NP_001367152.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12279660..12281913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027885.5 → NP_001023056.1  Aminopeptidase ltah-1.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023056.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A3QMC1, A3QMC2, G5EFT4
    Conserved Domains (2) summary
    cd09599
    Location:8 → 453
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam09127
    Location:468 → 608
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

  2. NM_001380482.2 → NP_001367152.1  Aminopeptidase ltah-1.1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl14813
    Location:8 → 128
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  3. NM_001027887.6 → NP_001023058.1  Aminopeptidase ltah-1.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFT4
    Conserved Domains (3) summary
    cd09599
    Location:8 → 452
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:8 → 599
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:469 → 604
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFT4.1

Gene LinkOut

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