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slc-5A12 Sodium-dependent multivitamin transporter [ Caenorhabditis elegans ]

Gene ID: 178127, updated on 4-Jan-2025

Summary

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Official Symbol
slc-5A12
Official Full Name
Sodium-dependent multivitamin transporter
Primary source
WormBase:WBGene00014092
Locus tag
CELE_ZK822.5
See related
AllianceGenome:WB:WBGene00014092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in plasma membrane. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to several human genes including SLC5A12 (solute carrier family 5 member 12) and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See slc-5A12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (11937418..11940604)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene putative Na(+)/H(+) antiporter nhx-9 Neighboring gene ncRNA Neighboring gene DeHydrogenases, Short chain Neighboring gene Glycosyltransferase family 92 protein Neighboring gene putative aromatic-L-amino-acid decarboxylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sodium-dependent multivitamin transporter
NP_001041067.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11937418..11940604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047602.6 → NP_001041067.1  Sodium-dependent multivitamin transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041067.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23616
    Conserved Domains (1) summary
    cd11492
    Location:11 → 540
    SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
Nucleotide Protein
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Gene LinkOut

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