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lys-4 LYSozyme [ Caenorhabditis elegans ]

Gene ID: 178086, updated on 4-Jan-2025

Summary

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Official Symbol
lys-4
Official Full Name
LYSozyme
Primary source
WormBase:WBGene00003093
Locus tag
CELE_F58B3.1
See related
AllianceGenome:WB:WBGene00003093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lysozyme activity. Involved in defense response to Gram-positive bacterium. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lys-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_003282.8 (11621429..11623174, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Delta-like protein Neighboring gene ncRNA Neighboring gene Lysozyme-like protein 5 Neighboring gene LYSozyme

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. Irazoqui JE, et al. PLoS Pathog, 2010 Jul 1. PMID 20617181, Free PMC Article
  2. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article
  3. Inducible antibacterial defense system in C. elegans. Mallo GV, et al. Curr Biol, 2002 Jul 23. PMID 12176330
  4. Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response. Mokoena NZ, et al. Med Microbiol Immunol, 2023 Oct. PMID 37672050, Free PMC Article
  5. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas HR, et al. Mol Immunol, 2004 Jul. PMID 15183927

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LYSozyme
NP_502192.1
  • Product from WormBase gene class lys;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11621429..11623174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069791.9 → NP_502192.1  LYSozyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502192.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20964
    Conserved Domains (1) summary
    cd06416
    Location:19 → 212
    GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
Nucleotide Protein
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