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cyp-31A2 CYtochrome P450 family [ Caenorhabditis elegans ]

Gene ID: 178065, updated on 4-Jan-2025

Summary

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Official Symbol
cyp-31A2
Official Full Name
CYtochrome P450 family
Primary source
WormBase:WBGene00010354
Locus tag
CELE_H02I12.8
See related
AllianceGenome:WB:WBGene00010354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in several processes, including asymmetric cell division; eggshell formation; and polar body extrusion after meiotic divisions. Used to study Bietti crystalline corneoretinal dystrophy. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cyp-31A2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (11403961..11406091)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Histone H2A Neighboring gene ncRNA Neighboring gene MEiosis-to-MItosis transition associated Neighboring gene Histone H3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo. Benenati G, et al. Mech Dev, 2009 May-Jun. PMID 19368796
  2. Xenobiotic detoxification in the nematode Caenorhabditis elegans. Lindblom TH, et al. J Exp Zool A Comp Exp Biol, 2006 Sep 1. PMID 16902959, Free PMC Article
  3. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
  4. Changes in Nuclear Receptor and Vitellogenin Gene Expression in Response to Steroids and Heavy Metal in Caenorhabditis elegans. Novillo A, et al. Integr Comp Biol, 2005 Jan. PMID 21676746
  5. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of both cyp-31A2 and cyp-31A3 either by RNAi or using a double deletion mutant, led to the failure of establishing the correct polarity of the embryo and to complete the extrusion of the polar bodies during meiosis.
    Title: Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asymmetric cell division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in eggshell formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryonic morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in polar body extrusion after meiotic divisions IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
CYtochrome P450 family
NP_502152.3
  • Product from WormBase gene class cyp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11403961..11406091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069751.7 → NP_502152.3  CYtochrome P450 family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502152.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGT6
    Conserved Domains (1) summary
    pfam00067
    Location:36 → 472
    p450; Cytochrome P450
Nucleotide Protein
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