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ard-1 3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2 [ Caenorhabditis elegans ]

Gene ID: 178016, updated on 2-Nov-2024

Summary

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Official Symbol
ard-1
Official Full Name
3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2
Primary source
WormBase:WBGene00000181
Locus tag
CELE_F01G4.2
See related
AllianceGenome:WB:WBGene00000181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in androgen metabolic process; estrogen metabolic process; and fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in pheochromocytoma and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ard-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (11131279..11133805)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Endoplasmin homolog Neighboring gene DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11 Neighboring gene SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 Neighboring gene Helicase SKI2W Neighboring gene ncRNA Neighboring gene CNH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of Caenorhabditis elegans pry-1/Axin suppressors identifies genes involved in reproductive structure development, stress responses, and aging. Mallick A, et al. G3 (Bethesda), 2022 Feb 4. PMID 35100345, Free PMC Article
  2. ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia. Mahapatra A, et al. PLoS Biol, 2023 Sep. PMID 37747897, Free PMC Article
  3. Xenobiotic detoxification in the nematode Caenorhabditis elegans. Lindblom TH, et al. J Exp Zool A Comp Exp Biol, 2006 Sep 1. PMID 16902959, Free PMC Article
  4. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Srinivasan S, et al. Cell Metab, 2008 Jun. PMID 18522834, Free PMC Article
  5. Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis. Tabuse Y, et al. Proteomics, 2005 Jul. PMID 15996007

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in androgen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in estrogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2
NP_001293993.1
  • Confirmed by transcript evidence
NP_502083.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11131279..11133805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069682.8 → NP_502083.1  3-hydroxyacyl-CoA dehydrogenase type-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502083.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19102
    Conserved Domains (2) summary
    cd05371
    Location:8 → 258
    HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
    PRK05557
    Location:6 → 257
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

  2. NM_001307064.3 → NP_001293993.1  3-hydroxyacyl-CoA dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293993.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AD09
    Conserved Domains (1) summary
    cl21454
    Location:1 → 84
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
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