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pges-2 Prostaglandin E synthase 2 [ Caenorhabditis elegans ]

Gene ID: 177925, updated on 4-Jan-2025

Summary

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Official Symbol
pges-2
Official Full Name
Prostaglandin E synthase 2
Primary source
WormBase:WBGene00011239
Locus tag
CELE_R11A8.5
See related
AllianceGenome:WB:WBGene00011239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable prostaglandin-E synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in ganglia; germ line; hypodermis; intestinal cell; and muscle cell. Orthologous to human PTGES2 (prostaglandin E synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pges-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10366333..10367790, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G-patch domain and KOW motifs-containing protein homolog 1 Neighboring gene glucuronosyltransferase Neighboring gene Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 Neighboring gene Isoleucine--tRNA ligase, cytoplasmic Neighboring gene PDZ domain-containing protein Neighboring gene Ankyrin repeat and KH domain-containing protein mask-1;K Homology domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E(2) alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field. Sun Y, et al. Int J Radiat Biol, 2018 Dec. PMID 30307357
  2. The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction. Bamps S, et al. Mech Ageing Dev, 2009 Nov-Dec. PMID 19896965
  3. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin-E synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Prostaglandin E synthase 2
NP_501913.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10366333..10367790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069512.8 → NP_501913.1  Prostaglandin E synthase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21925
    Conserved Domains (3) summary
    cd03197
    Location:183 → 334
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    COG0625
    Location:66 → 331
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:65 → 138
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
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