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ebax-1 SWIM-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177915, updated on 9-Dec-2024

Summary

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Official Symbol
ebax-1
Official Full Name
SWIM-type domain-containing protein
Primary source
WormBase:WBGene00004140
Locus tag
CELE_R09E10.7
See related
AllianceGenome:WB:WBGene00004140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables Hsp90 protein binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of egg-laying behavior; positive regulation of miRNA catabolic process; and regulation of male mating behavior. Located in axon; cytosol; and neuronal cell body. Part of Cul2-RING ubiquitin ligase complex. Is expressed in excretory cell; nervous system; and vulval muscle. Orthologous to human ZSWIM8 (zinc finger SWIM-type containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ebax-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (10286955..10293013)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Thymidine kinase Neighboring gene DNA repair protein RAD51 homolog Neighboring gene PH domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamics of miRNA accumulation during C. elegans larval development. Nahar S, et al. Nucleic Acids Res, 2024 May 22. PMID 38381904, Free PMC Article
  2. Catalytic residues of microRNA Argonautes play a modest role in microRNA star strand destabilization in C. elegans. Kotagama K, et al. Nucleic Acids Res, 2024 May 22. PMID 38471816, Free PMC Article
  3. The developmentally timed decay of an essential microRNA family is seed-sequence dependent. Donnelly BF, et al. Cell Rep, 2022 Aug 9. PMID 35947946, Free PMC Article
  4. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Wang Z, et al. Neuron, 2013 Sep 4. PMID 24012004, Free PMC Article
  5. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of miRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of male mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SWIM-type domain-containing protein
NP_501888.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10286955..10293013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069487.7 → NP_501888.2  SWIM-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501888.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21875
Nucleotide Protein
Heading Accession and Version

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