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qns-1 Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177900, updated on 4-Jan-2025

Summary

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Official Symbol
qns-1
Official Full Name
Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein
Primary source
WormBase:WBGene00007698
Locus tag
CELE_C24F3.4
See related
AllianceGenome:WB:WBGene00007698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables NAD+ synthase activity. Involved in NAD biosynthetic process and determination of adult lifespan. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See qns-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (10214986..10219308, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Serpentine receptor class gamma Neighboring gene ABC transporter domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Translocating chain-associated membrane protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Mouchiroud L, et al. Cell, 2013 Jul 18. PMID 23870130, Free PMC Article
  2. Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Yang W, et al. Aging Cell, 2010 Jun. PMID 20346072
  3. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein
NP_001255472.1
  • Confirmed by transcript evidence
NP_001255473.1
  • Confirmed by transcript evidence
NP_001255474.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10214986..10219308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268543.4 → NP_001255472.1  Glutamine-dependent NAD(+) synthetase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255472.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXK6
    Conserved Domains (3) summary
    cd07570
    Location:9 → 298
    GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
    PLN02339
    Location:6 → 702
    PLN02339; NAD+ synthase (glutamine-hydrolysing)
    cd00553
    Location:334 → 654
    NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

  2. NM_001268544.3 → NP_001255473.1  Glutamine-dependent NAD(+) synthetase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255473.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3Y5P6
    Conserved Domains (2) summary
    cd07570
    Location:2 → 227
    GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
    cd00553
    Location:263 → 583
    NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

  3. NM_001268545.3 → NP_001255474.1  NAD/GMP synthase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255474.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3Y5P7
    Conserved Domains (1) summary
    PLN02339
    Location:1 → 278
    PLN02339; NAD+ synthase (glutamine-hydrolysing)
Nucleotide Protein
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