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cwn-2 Protein Wnt-2 [ Caenorhabditis elegans ]

Gene ID: 177870, updated on 2-Nov-2024

Summary

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Official Symbol
cwn-2
Official Full Name
Protein Wnt-2
Primary source
WormBase:WBGene00000858
Locus tag
CELE_W01B6.1
See related
AllianceGenome:WB:WBGene00000858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including axis specification; neuroblast migration; and neuron migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including P5.ppp; P7.paa; head neurons; hypodermis; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1 and congenital diarrhea. Orthologous to several human genes including WNT5A (Wnt family member 5A) and WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cwn-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10067816..10070251)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PNPLA domain-containing protein Neighboring gene ncRNA Neighboring gene MFS domain-containing protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene 3-deoxy-7-phosphoheptulonate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Wnt Ligands Differentially Regulate Toxicity and Translocation of Graphene Oxide through Different Mechanisms in Caenorhabditis elegans. Zhi L, et al. Sci Rep, 2016 Dec 13. PMID 27958363, Free PMC Article
  2. A multi-trap microfluidic chip enabling longitudinal studies of nerve regeneration in Caenorhabditis elegans. Gokce SK, et al. Sci Rep, 2017 Aug 29. PMID 28852096, Free PMC Article
  3. Involvement of YAP-1, the Homolog of Yes-Associated Protein, in the Wnt-Mediated Neuronal Polarization in Caenorhabditis elegans. Lee H, et al. G3 (Bethesda), 2018 Jul 31. PMID 29853655, Free PMC Article
  4. Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in Caenorhabditis elegans. Wang J, et al. Proc Natl Acad Sci U S A, 2018 Mar 6. PMID 29463707, Free PMC Article
  5. Wnts Promote Synaptic Assembly Through T-Cell Specific Transcription Factors in Caenorhabditis elegans. Shi Y, et al. Front Mol Neurosci, 2018. PMID 29962933, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAX-3 binds to Wnt/CWN-2 and facilitates the membrane recruitment of CWN-2. SAX-3 forms a complex with the Ror/CAM-1 receptor and its downstream effector Dsh/DSH-1.
    Title: Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in Caenorhabditis elegans.
  2. our results strongly suggest that functions of at least four Wnts (lin-44, cwn-1, cwn-2, and egl-20) determine the polarity orientation of seam cells
    Title: Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
  3. In contrast to other Wnt mutants that act in the posterior body, cwn-2 mutants have severe defects in the anterior nervous system
    Title: Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables receptor ligand activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anterior/posterior axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate specification involved in pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in generation of neurons IEA
Inferred from Electronic Annotation
more info
  
involved_in interneuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in interneuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in motor neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuroblast migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of motor neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in specification of animal organ axis polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein Wnt-2
NP_501822.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10067816..10070251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069421.6 → NP_501822.1  Protein Wnt-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501822.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34889
    Conserved Domains (1) summary
    pfam00110
    Location:51 → 360
    wnt; wnt family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34889.2

Gene LinkOut

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