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gipc-2 PDZ domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177865, updated on 9-Dec-2024

Summary

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Official Symbol
gipc-2
Official Full Name
PDZ domain-containing protein
Primary source
WormBase:WBGene00009681
Locus tag
CELE_F44D12.4
See related
AllianceGenome:WB:WBGene00009681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Is expressed in intestine; nervous system; and spermatid. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 15 and oculopharyngodistal myopathy 2. Orthologous to several human genes including GIPC1 (GIPC PDZ domain containing family member 1) and GIPC3 (GIPC PDZ domain containing family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gipc-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (10026413..10027666, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MSP domain-containing protein Neighboring gene PHD-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene MSP domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of gipc-1 and gipc-2 causes infertility in Caenorhabditis elegans by reducing sperm motility. Kim J, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33280819
  2. Distinct roles of two myosins in C. elegans spermatid differentiation. Hu J, et al. PLoS Biol, 2019 Apr. PMID 30990821, Free PMC Article
  3. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
  4. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of gipc-1 and gipc-2 causes infertility in Caenorhabditis elegans by reducing sperm motility.
    Title: Depletion of gipc-1 and gipc-2 causes infertility in Caenorhabditis elegans by reducing sperm motility.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
PDZ domain-containing protein
NP_501810.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10026413..10027666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069409.6 → NP_501810.2  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501810.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20393
    Conserved Domains (1) summary
    cd00992
    Location:138 → 209
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein
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