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C47E12.3 alpha-1,2-Mannosidase [ Caenorhabditis elegans ]

Gene ID: 177857, updated on 14-Nov-2024

Summary

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Official Symbol
C47E12.3
Official Full Name
alpha-1,2-Mannosidase
Primary source
WormBase:WBGene00008148
Locus tag
CELE_C47E12.3
See related
AllianceGenome:WB:WBGene00008148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in head neurons and intestine. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See C47E12.3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (9999160..10001848, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein Neighboring gene E1 ubiquitin-activating enzyme Neighboring gene Inorganic pyrophosphatase 1 Neighboring gene ADP/ATP translocase Neighboring gene putative serine--tRNA ligase, cytoplasmic Neighboring gene DUF1874 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum mannose trimming IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,2-Mannosidase
NP_001293897.1
  • Partially confirmed by transcript evidence
NP_501802.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9999160..10001848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306968.3 → NP_001293897.1  alpha-1,2-Mannosidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACH9
    Conserved Domains (1) summary
    pfam01532
    Location:54 → 498
    Glyco_hydro_47; Glycosyl hydrolase family 47

  2. NM_069401.6 → NP_501802.2  alpha-1,2-Mannosidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501802.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18679
    Conserved Domains (1) summary
    pfam01532
    Location:54 → 504
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein
Heading Accession and Version

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