gln-6 glutamine synthetase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gln-6
Official Full Name: glutamine synthetase
Primary source: WormBase:WBGene00001607
Locus tag: CELE_C28D4.3
See related: AllianceGenome:WB:WBGene00001607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in anterior gonad arm and germ line. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gln-6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (9739261..9740901, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C28D4.3 (e-PCR)
- UniSTS:309174

C28D4.4 (e-PCR)
- UniSTS:309175

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glutamine synthetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamine synthetase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamine synthetase

NP_501733.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9739261..9740901 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069332.6 → NP_501733.1 glutamine synthetase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501733.1

Status: REVIEWED

UniProtKB/TrEMBL

O02225

Conserved Domains (1) summary

PLN02284
Location:29 → 368

PLN02284; glutamine synthetase