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vha-17 V-type proton ATPase subunit e [ Caenorhabditis elegans ]

Gene ID: 177757, updated on 9-Dec-2024

Summary

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Official Symbol
vha-17
Official Full Name
V-type proton ATPase subunit e
Primary source
WormBase:WBGene00009882
Locus tag
CELE_F49C12.13
See related
AllianceGenome:WB:WBGene00009882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development; embryonic body morphogenesis; and regulation of syncytium formation by plasma membrane fusion. Located in apical junction complex and apical plasma membrane. Is expressed in excretory cell; hypodermal cell; and intestine. Orthologous to several human genes including ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vha-17 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (9321801..9322525)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 26S proteasome non-ATPase regulatory subunit 6 Neighboring gene Methyltransferase type 11 domain-containing protein Neighboring gene Translation machinery-associated protein 7 homolog Neighboring gene DUF1648 domain-containing protein;Ribonuclease kappa Neighboring gene DUF19 domain-containing protein Neighboring gene Serine/arginine repetitive matrix protein 2-like Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex. Kontani K, et al. Dev Cell, 2005 May. PMID 15866168
  2. glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis. Rabbitts BM, et al. Genetics, 2008 Oct. PMID 18780725, Free PMC Article
  3. Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy. Bott LC, et al. Brain Commun, 2021. PMID 34909687, Free PMC Article
  4. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717
  5. Cell fusion. Podbilewicz B. WormBook, 2006 Jan 6. PMID 18050486, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of syncytium formation by plasma membrane fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of syncytium formation by plasma membrane fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of plasma membrane proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit e
NP_501636.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9321801..9322525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069235.10 → NP_501636.2  V-type proton ATPase subunit e [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501636.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20591
    Conserved Domains (1) summary
    pfam05493
    Location:6 → 64
    ATP_synt_H; ATP synthase subunit H
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20591.2

Gene LinkOut

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