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fem-3 Sex-determination protein fem-3 [ Caenorhabditis elegans ]

Gene ID: 177734, updated on 4-Jan-2025

Summary

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Official Symbol
fem-3
Official Full Name
Sex-determination protein fem-3
Primary source
WormBase:WBGene00001413
Locus tag
CELE_C01F6.4
See related
AllianceGenome:WB:WBGene00001413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein phosphatase binding activity. Involved in several processes, including male somatic sex determination; masculinization of hermaphroditic germ-line; and positive regulation of macromolecule metabolic process. Located in cytoplasm. Part of protein-containing complex. Is expressed in germ line; spermatid; and in male. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fem-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (9104966..9107607)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Ovule protein Neighboring gene Chromatin target of PRMT1 protein C-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein. Wang Y, et al. Proc Natl Acad Sci U S A, 2009 Dec 1. PMID 19901328, Free PMC Article
  2. Repression by the 3' UTR of fem-3, a sex-determining gene, relies on a ubiquitous mog-dependent control in Caenorhabditis elegans. Gallegos M, et al. EMBO J, 1998 Nov 2. PMID 9799241, Free PMC Article
  3. The sperm-oocyte switch in the C. elegans hermaphrodite is controlled through steady-state levels of the fem-3 mRNA. Zanetti S, et al. RNA, 2012 Jul. PMID 22635404, Free PMC Article
  4. Sex determination in the Caenorhabditis elegans germline. Zanetti S, et al. Adv Exp Med Biol, 2013. PMID 22872474
  5. A comparison of mutations induced by accelerated iron particles versus those induced by low earth orbit space radiation in the FEM-3 gene of Caenorhabditis elegans. Hartman PS, et al. Mutat Res, 2001 Mar 1. PMID 11239962

See all (233) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that the N-terminal domain (NTD) works in mediating the sex-determining role of FEM-1/2/3 complex.
    Title: Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.
  2. It was shown that FEM-3 is exclusively present in germ cells that are committed to spermatogenesis. In fem- 3(gf)/+ heterozygotes, mutant fem-3 gain-of-function transcripts are more abundant than their wild-type counterpart.
    Title: The sperm-oocyte switch in the C. elegans hermaphrodite is controlled through steady-state levels of the fem-3 mRNA.
  3. Pumilio-fem-3 mRNA binding factor (PUF) RNA-binding proteins achieve that specificity through variations on a conserved scaffold.
    Title: Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket.
  4. our data indicate that LARP-1 and NOS-3 promote oogenesis by regulating fem-3 expression through distinct mechanisms.
    Title: LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.
  5. Results suggest that SEL-10-mediated proteolysis of FEM-1 and FEM-3 is required for normal hermaphrodite development.
    Title: The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in male sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male somatic sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in masculinization of hermaphroditic germ-line IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of germ cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Sex-determination protein fem-3
NP_001255365.1
  • Confirmed by transcript evidence
NP_001255366.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9104966..9107607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268436.4 → NP_001255365.1  Sex-determination protein fem-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255365.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34691

  2. NM_001268437.3 → NP_001255366.1  Sex-determination protein fem-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255366.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L280

RNA

  1. NR_056354.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34691.1

Gene LinkOut

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Chemical Information
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