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cfim-2 Cleavage and polyadenylation specificity factor subunit 6;RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177710, updated on 2-Nov-2024

Summary

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Official Symbol
cfim-2
Official Full Name
Cleavage and polyadenylation specificity factor subunit 6;RRM domain-containing protein
Primary source
WormBase:WBGene00008362
Locus tag
CELE_D1046.1
See related
AllianceGenome:WB:WBGene00008362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA alternative polyadenylation. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including anal depressor muscle; coelomocyte; head mesodermal cell; rectum; and reproductive system. Orthologous to several human genes including CPSF7 (cleavage and polyadenylation specific factor 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cfim-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (8926328..8930346)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene Mitochondrial carrier protein PET8 Neighboring gene Uncharacterized protein Neighboring gene MFS domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
  2. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
  3. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  4. PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut. Kiefer JC, et al. Dev Biol, 2007 Mar 15. PMID 17250823, Free PMC Article
  5. Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline. Walhout AJ, et al. Curr Biol, 2002 Nov 19. PMID 12445390

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA alternative polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cleavage and polyadenylation specificity factor subunit 6;RRM domain-containing protein
NP_001367218.1
  • Confirmed by transcript evidence
NP_001368144.1
  • Confirmed by transcript evidence
NP_001369896.1
  • Confirmed by transcript evidence
NP_001370253.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8926328..8930346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380391.2 → NP_001367218.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6KRJ2
    Conserved Domains (1) summary
    cd12643
    Location:85 → 163
    RRM_CFIm68; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

  2. NM_001383157.2 → NP_001369896.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18937
    Conserved Domains (2) summary
    TIGR01628
    Location:251 → 362
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12643
    Location:85 → 163
    RRM_CFIm68; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

  3. NM_001383156.2 → NP_001370253.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1P629
    Conserved Domains (2) summary
    TIGR01628
    Location:253 → 364
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12643
    Location:87 → 165
    RRM_CFIm68; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

  4. NM_001380392.1 → NP_001368144.1  Cleavage and polyadenylation specificity factor subunit 6 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    I7KSC2
    Conserved Domains (1) summary
    TIGR01628
    Location:55 → 166
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
Nucleotide Protein
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