F21D5.5 Uncharacterized protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F21D5.5
Official Full Name: Uncharacterized protein
Primary source: WormBase:WBGene00009010
Locus tag: CELE_F21D5.5
See related: AllianceGenome:WB:WBGene00009010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables double-stranded DNA binding activity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2; ataxia-oculomotor apraxia type 4; and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F21D5.5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (8735695..8739394, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F21D5.5 (e-PCR)
- UniSTS:307516

F21D5.4 (e-PCR)
- UniSTS:309864

F21D5.6 (e-PCR)
- UniSTS:321385

F21D5.8 (e-PCR)
- UniSTS:320506

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Uncharacterized protein

NP_501503.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8735695..8739394 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069102.6 → NP_501503.1 Uncharacterized protein CELE_F21D5.5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501503.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19683, Q9GQ64

Conserved Domains (5) summary

cd01427
Location:53 → 174

HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

pfam08645
Location:52 → 211

PNK3P; Polynucleotide kinase 3 phosphatase

pfam13671
Location:252 → 374

AAA_33; AAA domain

cl13995
Location:181 → 279

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

cl17190
Location:252 → 407

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...