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C08G9.2 Uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 177545, updated on 9-Dec-2024

Summary

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Official Symbol
C08G9.2
Official Full Name
Uncharacterized protein
Primary source
WormBase:WBGene00015620
Locus tag
CELE_C08G9.2
See related
AllianceGenome:WB:WBGene00015620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in head neurons and pharynx. Orthologous to several human genes including WFDC10A (WAP four-disulfide core domain 10A); WFDC10B (WAP four-disulfide core domain 10B); and WFDC11 (WAP four-disulfide core domain 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See C08G9.2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
26
Sequence:
Chromosome: IV; NC_003282.8 (7664157..7672972, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inositol 1,4,5-trisphosphate receptor itr-1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Uncharacterized protein
NP_501249.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7664157..7672972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068848.4 → NP_501249.1  Uncharacterized protein CELE_C08G9.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501249.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44131
    Conserved Domains (5) summary
    smart00211
    Location:577 → 619
    TY; Thyroglobulin type I repeats
    cd00191
    Location:1705 → 1768
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:1946 → 1997
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:90 → 127
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam14625
    Location:1898 → 1940
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
Nucleotide Protein
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