nprl-2 Nitrogen permease regulator 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nprl-2
Official Full Name: Nitrogen permease regulator 2
Primary source: WormBase:WBGene00018635
Locus tag: CELE_F49E8.1
See related: AllianceGenome:WB:WBGene00018635
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to contribute to GTPase activator activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be part of GATOR1 complex. Predicted to be active in vacuolar membrane. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 2. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nprl-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (7556816..7558761)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reports an important role for N-methyl-transferase (NNMT) in regulation of autophagy during aging, where high neuronal ANMT-1 (the C. elegans NNMT ortholog) activity induces autophagy via NPRL-2, which maintains neuronal function in old wild type animals and various disease models, also affecting longevity.
Title: Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F49E8.1 (e-PCR)
- UniSTS:311697

F49E8.7 (e-PCR)
- UniSTS:311701

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GATOR1 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Nitrogen permease regulator 2

NP_001380164.1

Confirmed by transcript evidence

NP_001380165.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7556816..7558761

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392333.1 → NP_001380165.1 Nitrogen permease regulator 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

W6RQZ3

Conserved Domains (1) summary

pfam06218
Location:37 → 444

NPR2; Nitrogen permease regulator 2
NM_001392334.1 → NP_001380164.1 Nitrogen permease regulator 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

W6SBD7

Conserved Domains (1) summary

pfam06218
Location:37 → 426

NPR2; Nitrogen permease regulator 2