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R05G6.4 Nitric oxide synthase-interacting protein homolog [ Caenorhabditis elegans ]

Gene ID: 177526, updated on 9-Dec-2024

Summary

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Official Symbol
R05G6.4
Official Full Name
Nitric oxide synthase-interacting protein homolog
Primary source
WormBase:WBGene00019898
Locus tag
CELE_R05G6.4
See related
AllianceGenome:WB:WBGene00019898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See R05G6.4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (7513233..7514407)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uroporphyrinogen-III synthase Neighboring gene Phosphoinositide phospholipase C Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene Venom peptide

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nitric oxide synthase-interacting protein homolog
NP_501214.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7513233..7514407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068813.10 → NP_501214.1  Nitric oxide synthase-interacting protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501214.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21755
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cl17238
    Location:190 → 285
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21755.1

Gene LinkOut

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