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vha-8 V-type proton ATPase subunit E [ Caenorhabditis elegans ]

Gene ID: 177442, updated on 4-Jan-2025

Summary

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Official Symbol
vha-8
Official Full Name
V-type proton ATPase subunit E
Primary source
WormBase:WBGene00006917
Locus tag
CELE_C17H12.14
See related
AllianceGenome:WB:WBGene00006917
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Located in apical plasma membrane and cytoplasm. Is expressed in several structures, including excretory cell; head; hypodermis; intestine; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Orthologous to several human genes including ATP6V1E2 (ATPase H+ transporting V1 subunit E2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See vha-8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (6791074..6792455)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mab-21 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein-tyrosine phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vacuolar-type H+-ATPase E subunit is required for embryogenesis and yolk transfer in Caenorhabditis elegans. Choi KY, et al. Gene, 2003 Jun 5. PMID 12853134
  2. VHA-8, the E subunit of V-ATPase, is essential for pH homeostasis and larval development in C. elegans. Ji YJ, et al. FEBS Lett, 2006 May 29. PMID 16684534
  3. Molecular markers of differentiation in Caenorhabditis elegans obtained by promoter trapping. Young JM, et al. Dev Dyn, 1993 Feb. PMID 8364222
  4. Caenorhabditis elegans homologue of Prox1/Prospero is expressed in the glia and is required for sensory behavior and cold tolerance. Kage-Nakadai E, et al. Genes Cells, 2016 Sep. PMID 27402188
  5. A proteomic view of Caenorhabditis elegans caused by short-term hypoxic stress. Li H, et al. Proteome Sci, 2010 Sep 21. PMID 20858264, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Caenorhabditis elegans vha-8 encodes the E subunit of V-ATPase which is expressed in the hypodermis, intestine and H-shaped excretory cells.
    Title: VHA-8, the E subunit of V-ATPase, is essential for pH homeostasis and larval development in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting two-sector ATPase complex, catalytic domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit E
NP_501040.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6791074..6792455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068639.8 → NP_501040.1  V-type proton ATPase subunit E [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501040.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95X44
    Conserved Domains (2) summary
    COG1390
    Location:9 → 218
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam01991
    Location:18 → 216
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95X44.1

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