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tat-2 Phospholipid-transporting ATPase [ Caenorhabditis elegans ]

Gene ID: 177256, updated on 4-Jan-2025

Summary

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Official Symbol
tat-2
Official Full Name
Phospholipid-transporting ATPase
Primary source
WormBase:WBGene00019166
Locus tag
CELE_H06H21.10
See related
AllianceGenome:WB:WBGene00019166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in sterol metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including excretory system; gonad; pharynx; rectal gland cell; and vulva. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to several human genes including ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tat-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
24
Sequence:
Chromosome: IV; NC_003282.8 (4827853..4846893, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegans. Seamen E, et al. PLoS Genet, 2009 Aug. PMID 19662161, Free PMC Article
  2. Mitochondrial oxidative stress alters a pathway in Caenorhabditis elegans strongly resembling that of bile acid biosynthesis and secretion in vertebrates. Liu JL, et al. PLoS Genet, 2012. PMID 22438816, Free PMC Article
  3. The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Shida T, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21068373, Free PMC Article
  4. An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases. Lyssenko NN, et al. BMC Dev Biol, 2008 Oct 2. PMID 18831765, Free PMC Article
  5. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Darland-Ransom M, et al. Science, 2008 Apr 25. PMID 18436785

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAT-2 has a specific role in antagonizing the regulatory activity of monomethyl branched-chain fatty acid in intestinal cells.
    Title: P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phospholipid-transporting ATPase
NP_001023252.2
  • Confirmed by transcript evidence
NP_001294444.1
  • Confirmed by transcript evidence
NP_001294445.1
  • Partially confirmed by transcript evidence
NP_001294446.1
  • Confirmed by transcript evidence
NP_001294447.1
  • Confirmed by transcript evidence
NP_001367920.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4827853..4846893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307517.3 → NP_001294446.1  Phospholipid-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294446.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBI0
    Conserved Domains (6) summary
    TIGR01652
    Location:71 → 1178
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:526 → 615
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:60 → 122
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:916 → 1172
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl00297
    Location:675 → 738
    R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
    cl21460
    Location:885 → 916
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_001307518.3 → NP_001294447.1  Phospholipid-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294447.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBV8
    Conserved Domains (6) summary
    TIGR01652
    Location:71 → 1178
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:526 → 615
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:60 → 122
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:916 → 1172
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl00297
    Location:675 → 738
    R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
    cl21460
    Location:885 → 916
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. NM_001380211.1 → NP_001367920.1  Phospholipid-transporting ATPase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YXV5
    Conserved Domains (1) summary
    cd02073
    Location:38 → 1013
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  4. NM_001028081.3 → NP_001023252.2  Phospholipid-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023252.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TXV2
    Conserved Domains (6) summary
    TIGR01652
    Location:36 → 1143
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:491 → 580
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:25 → 87
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:881 → 1137
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl00297
    Location:640 → 703
    R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
    cl21460
    Location:850 → 881
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  5. NM_001307516.1 → NP_001294445.1  Phospholipid-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294445.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEQ6
    Conserved Domains (6) summary
    TIGR01652
    Location:71 → 1178
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:526 → 615
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:60 → 122
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:916 → 1172
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl00297
    Location:675 → 738
    R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
    cl21460
    Location:885 → 916
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  6. NM_001307515.3 → NP_001294444.1  Phospholipid-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294444.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRL1
    Conserved Domains (6) summary
    TIGR01652
    Location:36 → 1143
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:491 → 580
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:25 → 87
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:881 → 1137
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl00297
    Location:640 → 703
    R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
    cl21460
    Location:850 → 881
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
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