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elac-2 Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z [ Caenorhabditis elegans ]

Gene ID: 177241, updated on 4-Jan-2025

Summary

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Official Symbol
elac-2
Official Full Name
Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z
Primary source
WormBase:WBGene00001983
Locus tag
CELE_E04A4.4
See related
AllianceGenome:WB:WBGene00001983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-tRNA processing endoribonuclease activity. Involved in several processes, including germ cell development; nematode larval development; and positive regulation of vulval development. Predicted to be located in nucleus. Predicted to be active in mitochondrion. Is expressed in germ line. Used to study prostate cancer. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See elac-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (4739490..4744267, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene F-box associated domain-containing protein Neighboring gene putative mitochondrial import inner membrane translocase subunit tim-17B.1 Neighboring gene Tectonic domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation. Smith MM, et al. Dev Biol, 2004 Feb 1. PMID 14729485
  2. A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. Held JP, et al. Elife, 2022 Apr 22. PMID 35451962, Free PMC Article
  3. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article
  4. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Xia Q, et al. Redox Biol, 2023 Apr. PMID 36791646, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. required for hyperproliferation phenotypes seen with mutations in three different genes, suggesting it may be generally required for germline proliferation
    Title: The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z
NP_001023109.1
  • Partially confirmed by transcript evidence
NP_001023110.1
  • Confirmed by transcript evidence
NP_001294339.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4739490..4744267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027938.7 → NP_001023109.1  Zinc phosphodiesterase ELAC protein 2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023109.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44476, Q688B7
    Conserved Domains (3) summary
    COG1234
    Location:493 → 786
    ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
    cd07718
    Location:494 → 719
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cl23716
    Location:122 → 304
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  2. NM_001027939.4 → NP_001023110.1  Zinc phosphodiesterase ELAC protein 2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023110.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44476
    Conserved Domains (3) summary
    COG1234
    Location:420 → 713
    ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
    cd07718
    Location:421 → 646
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cl23716
    Location:49 → 231
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  3. NM_001307410.3 → NP_001294339.1  ribonuclease Z [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294339.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PR60
    Conserved Domains (1) summary
    cl23716
    Location:3 → 38
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44476.2

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