psr-1 Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: psr-1
Official Full Name: Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein
Primary source: WormBase:WBGene00004205
Locus tag: CELE_F29B9.4
See related: AllianceGenome:WB:WBGene00004205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity and phosphatidylserine binding activity. Involved in engulfment of apoptotic cell. Located in plasma membrane. Is expressed in engulfing cell. Orthologous to human JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See psr-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (4653293..4655848)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells.
Title: A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells.
findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis
Title: Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F29B9.5 (e-PCR)
- UniSTS:322092

F29B9.4 (e-PCR)
- UniSTS:307081

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables P-TEFb complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-lysine 5-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in engulfment of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein

NP_001040941.1

Confirmed by transcript evidence

NP_001294382.1

Confirmed by transcript evidence

NP_001379906.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4653293..4655848

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307453.3 → NP_001294382.1 JmjC domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294382.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBL8

Conserved Domains (2) summary

pfam02373
Location:195 → 308

JmjC; JmjC domain, hydroxylase

cl01487
Location:126 → 209

DUF1007; Protein of unknown function (DUF1007)
NM_001392301.1 → NP_001379906.1 Bifunctional arginine demethylase and lysyl-hydroxylase psr-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GYI4

Conserved Domains (1) summary

cl40423
Location:62 → 293

cupin_RmlC-like; RmlC-like cupin superfamily
NM_001047476.5 → NP_001040941.1 JmjC domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040941.1

Status: REVIEWED

UniProtKB/TrEMBL

Q27GT3

Conserved Domains (1) summary

pfam02373
Location:63 → 176

JmjC; JmjC domain, hydroxylase