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mt-Cytb cytochrome b, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17711, updated on 27-Dec-2024

Summary

Official Symbol
mt-Cytbprovided by MGI
Official Full Name
cytochrome b, mitochondrialprovided by MGI
Primary source
MGI:MGI:102501
See related
AllianceGenome:MGI:102501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CYTB
Summary
Predicted to enable metal ion binding activity. Predicted to contribute to ubiquinol-cytochrome-c reductase activity. Predicted to be involved in several processes, including electron transport coupled proton transport; mitochondrial electron transport, ubiquinol to cytochrome c; and response to glucagon. Located in membrane and mitochondrion. Part of respiratory chain complex III. Is active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See mt-Cytb in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (14145..15288)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (14145..15288)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 5 Neighboring gene NADH dehydrogenase subunit 6 Neighboring gene tRNA-Glu Neighboring gene tRNA-Thr Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding  
enables protein-containing complex binding  
enables protein-containing complex binding  
contributes_to ubiquinol-cytochrome-c reductase activity  
enables ubiquinol-cytochrome-c reductase activity  
Process Evidence Code Pubs
involved_in animal organ regeneration  
involved_in cellular respiration PubMed 
involved_in electron transport coupled proton transport  
involved_in electron transport coupled proton transport  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c PubMed 
involved_in response to cadmium ion  
involved_in response to cadmium ion  
involved_in response to calcium ion  
involved_in response to calcium ion  
involved_in response to cobalamin  
involved_in response to copper ion  
involved_in response to ethanol  
involved_in response to glucagon  
involved_in response to glucagon  
involved_in response to hyperoxia  
involved_in response to hypoxia  
involved_in response to mercury ion  
involved_in response to mercury ion  
involved_in response to toxic substance  
involved_in response to xenobiotic stimulus  
Component Evidence Code Pubs
is_active_in membrane  
located_in membrane PubMed 
is_active_in mitochondrial inner membrane PubMed 
located_in mitochondrial inner membrane PubMed 
located_in mitochondrial inner membrane  
located_in mitochondrion PubMed 
located_in mitochondrion PubMed 
part_of protein-containing complex  
part_of respiratory chain complex III  
part_of respiratory chain complex III PubMed 
part_of respiratory chain complex III  

General protein information

Names
cytochrome b
NP_904340.1
  • TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    14145..15288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904340.1 cytochrome b (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904340.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00158
    UniProtKB/TrEMBL
    A0A0F6PXN8, A0A0F6PYR5, A0A0F6PZ78, A0A650FQN5, A3R3Q8, B1P8W3, G3EBA2, Q401X6, Q5WA15, Q7JCZ3, Q7JCZ6, Q9TEY3
    Related
    ENSMUSP00000081003.1
    Conserved Domains (1) summary
    MTH00100
    Location:1378
    CYTB; cytochrome b; Provisional
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