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mdf-2 HORMA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177046, updated on 2-Nov-2024

Summary

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Official Symbol
mdf-2
Official Full Name
HORMA domain-containing protein
Primary source
WormBase:WBGene00003161
Locus tag
CELE_Y69A2AR.30
See related
AllianceGenome:WB:WBGene00003161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in embryo development; mitotic spindle assembly checkpoint signaling; and response to anoxia. Located in kinetochore; microtubule cytoskeleton; and nucleus. Is expressed in germ line. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mdf-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (2636229..2641025, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene NRAMP-like transporter smf-3 Neighboring gene Helix-loop-helix protein ngn-1 Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Neighboring gene Synembryn;Synembryn-A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans. Devigne A, et al. PLoS Genet, 2021 Nov. PMID 34762652, Free PMC Article
  2. Loss of the puromycin-sensitive aminopeptidase, PAM-1, triggers the spindle assembly checkpoint during the first mitotic division in Caenorhabditis elegans. Durkan A, et al. MicroPubl Biol, 2024. PMID 38633870, Free PMC Article
  3. Suspended animation in C. elegans requires the spindle checkpoint. Nystul TG, et al. Science, 2003 Nov 7. PMID 14605367
  4. TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. Nelson CR, et al. J Cell Biol, 2015 Nov 9. PMID 26527744, Free PMC Article
  5. Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans. Tarailo-Graovac M, et al. BMC Cell Biol, 2010 Sep 21. PMID 20858267, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.
    Title: Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.
  2. A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.
    Title: A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.
  3. spindle assembly checkpoint components MAD-1, MAD-2, and BUB-3 are required to negatively regulate synapsis and promote the synapsis checkpoint response.
    Title: Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to anoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
HORMA domain-containing protein
NP_001023563.1
  • Confirmed by transcript evidence
NP_001294613.1
  • Confirmed by transcript evidence
NP_001370850.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2636229..2641025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383055.1 → NP_001370850.1  HORMA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T870
    Conserved Domains (1) summary
    pfam02301
    Location:15 → 104
    HORMA; HORMA domain

  2. NM_001028392.8 → NP_001023563.1  HORMA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023563.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NGT3
    Conserved Domains (1) summary
    pfam02301
    Location:15 → 191
    HORMA; HORMA domain

  3. NM_001307684.3 → NP_001294613.1  HORMA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PC21
    Conserved Domains (1) summary
    pfam02301
    Location:11 → 128
    HORMA; HORMA domain
Nucleotide Protein
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