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fnip-2 UDENN FNIP1/2-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177012, updated on 2-Nov-2024

Summary

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Official Symbol
fnip-2
Official Full Name
UDENN FNIP1/2-type domain-containing protein
Primary source
WormBase:WBGene00020208
Locus tag
CELE_T04C4.1
See related
AllianceGenome:WB:WBGene00020208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1) and FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fnip-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (2222828..2236978)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene P3 protein Neighboring gene Eukaryotic translation initiation factor 3 30 kDa subunit Neighboring gene ncRNA Neighboring gene protein of unknown function WSN domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDENN FNIP1/2-type domain-containing protein
NP_001023357.2
  • Confirmed by transcript evidence
NP_001023358.2
  • Partially confirmed by transcript evidence
NP_001033430.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2222828..2236978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028187.5 → NP_001023358.2  UDENN FNIP1/2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023358.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0I9
    Conserved Domains (2) summary
    pfam14637
    Location:338 → 559
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:677 → 854
    FNIP_C; Folliculin-interacting protein C-terminus

  2. NM_001028186.5 → NP_001023357.2  UDENN FNIP1/2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023357.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0I8
    Conserved Domains (2) summary
    pfam14637
    Location:399 → 620
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:738 → 950
    FNIP_C; Folliculin-interacting protein C-terminus

  3. NM_001038341.3 → NP_001033430.1  UDENN FNIP1/2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4A572
Nucleotide Protein
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