ost-1 Kazal-like domain-containing protein;SPARC [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ost-1
Official Full Name: Kazal-like domain-containing protein;SPARC
Primary source: WormBase:WBGene00003893
Locus tag: CELE_C44B12.2
See related: AllianceGenome:WB:WBGene00003893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium ion binding activity. Located in basement membrane and extracellular space. Is expressed in several structures, including body wall musculature; enteric muscle; head mesodermal cell; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to several human genes including SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ost-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (1107396..1110872)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPARC functions normally to traffic collagen from its site of synthesis to tissues that do not express collagen.SPARC promotes anchor cell invasion by decreasing type IV collagen levels in the basement membrane.
Title: SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C44B12.2 (e-PCR)
- UniSTS:321984

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Kazal-like domain-containing protein;SPARC

NP_001368314.1

Confirmed by transcript evidence

NP_500039.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1107396..1110872

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067638.8 → NP_500039.1 SPARC [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500039.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34714

Conserved Domains (3) summary

cd00252
Location:140 → 264

SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

cd01328
Location:52 → 138

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

pfam10591
Location:139 → 250

SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
NM_001380031.1 → NP_001368314.1 Kazal-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PF73

Conserved Domains (2) summary

cd16231
Location:54 → 170

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins

cl00097
Location:2 → 51

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...