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dsc-4 Microsomal triglyceride transfer protein homolog [ Caenorhabditis elegans ]

Gene ID: 176852, updated on 9-Dec-2024

Summary

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Official Symbol
dsc-4
Official Full Name
Microsomal triglyceride transfer protein homolog
Primary source
WormBase:WBGene00001099
Locus tag
CELE_K02D7.4
See related
AllianceGenome:WB:WBGene00001099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lipid transfer activity and phospholipid transporter activity. Involved in lipoprotein transport and plasma lipoprotein particle assembly. Located in endoplasmic reticulum. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dsc-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (315056..320544, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Protein drl-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic and suppressor analysis of defecation in clk-1 mutants reveals that reaction to changes in temperature is an active process in Caenorhabditis elegans. Branicky R, et al. Genetics, 2001 Nov. PMID 11729148, Free PMC Article
  2. Regulation of lipoprotein assembly, secretion and fatty acid β-oxidation by Krüppel-like transcription factor, klf-3. Zhang J, et al. J Mol Biol, 2013 Aug 9. PMID 23639358, Free PMC Article
  3. Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution. Rava P, et al. Biochemistry, 2007 Oct 30. PMID 17924655, Free PMC Article
  4. Origin and evolution of yolk proteins: expansion and functional diversification of large lipid transfer protein superfamily. Wu LT, et al. Biol Reprod, 2013 Apr. PMID 23426435
  5. Redox regulation of germline and vulval development in Caenorhabditis elegans. Shibata Y, et al. Science, 2003 Dec 5. PMID 14657502

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phospholipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipoprotein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macromolecule localization IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in plasma lipoprotein particle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Microsomal triglyceride transfer protein homolog
NP_499903.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    315056..320544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067502.7 → NP_499903.3  Microsomal triglyceride transfer protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499903.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECG7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECG7.1

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