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R02D3.8 Exonuclease domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176845, updated on 14-Nov-2024

Summary

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Official Symbol
R02D3.8
Official Full Name
Exonuclease domain-containing protein
Primary source
WormBase:WBGene00019825
Locus tag
CELE_R02D3.8
See related
AllianceGenome:WB:WBGene00019825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-5'-RNA exonuclease activity. Involved in PERK-mediated unfolded protein response and innate immune response. Predicted to be active in cytoplasm. Orthologous to human ERI3 (ERI1 exoribonuclease family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See R02D3.8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (255966..257203, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Saccharopine dehydrogenase Neighboring gene Ground-like domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene WW domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in PERK-mediated unfolded protein response HEP PubMed 
involved_in innate immune response HEP PubMed 

General protein information

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Preferred Names
Exonuclease domain-containing protein
NP_499887.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    255966..257203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067486.4 → NP_499887.1  Exonuclease domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499887.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZZ9
    Conserved Domains (1) summary
    cd06133
    Location:61 → 240
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
Nucleotide Protein
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