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csn-3 COP9 signalosome complex subunit 3 [ Caenorhabditis elegans ]

Gene ID: 176834, updated on 2-Nov-2024

Summary

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Official Symbol
csn-3
Official Full Name
COP9 signalosome complex subunit 3
Primary source
WormBase:WBGene00000815
Locus tag
CELE_Y38C1AA.2
See related
AllianceGenome:WB:WBGene00000815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in establishment of mitotic spindle localization; mitotic cytokinesis; and ubiquitin-dependent protein catabolic process. Part of COP9 signalosome. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See csn-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (194742..202586)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene T-cell defective protein 2 Neighboring gene nicotinamidase Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene GTP cyclohydrolase 1 feedback regulatory protein Neighboring gene Cytochrome Oxidase Assembly subunits

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, et al. Curr Biol, 2003 May 27. PMID 12781129
  2. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
  3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
part_of COP9 signalosome IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 3
NP_499878.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    194742..202586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067477.9 → NP_499878.3  COP9 signalosome complex subunit 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499878.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N425
    Conserved Domains (1) summary
    pfam01399
    Location:338 → 432
    PCI; PCI domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N425.4

Gene LinkOut

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