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tyr-2 ShKT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176810, updated on 9-Dec-2024

Summary

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Official Symbol
tyr-2
Official Full Name
ShKT domain-containing protein
Primary source
WormBase:WBGene00010661
Locus tag
CELE_K08E3.1
See related
AllianceGenome:WB:WBGene00010661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables dopachrome isomerase activity. Involved in negative regulation of apoptotic process. Is expressed in hypodermis and uterine muscle. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to several human genes including TYR (tyrosinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tyr-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (13744222..13747287)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights into the evolution of metazoan tyrosinase gene family. Esposito R, et al. PLoS One, 2012. PMID 22536431, Free PMC Article
  2. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Sendoel A, et al. Nature, 2010 Jun 3. PMID 20520707, Free PMC Article
  3. Genetic interaction with temperature is an important determinant of nematode longevity. Miller H, et al. Aging Cell, 2017 Dec. PMID 28940623, Free PMC Article
  4. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dopachrome isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ShKT domain-containing protein
NP_499836.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13744222..13747287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067435.8 → NP_499836.1  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499836.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUS8
    Conserved Domains (3) summary
    smart00254
    Location:586 → 621
    ShKT; ShK toxin domain
    pfam00264
    Location:188 → 376
    Tyrosinase; Common central domain of tyrosinase
    pfam01549
    Location:541 → 576
    ShK; ShK domain-like
Nucleotide Protein
Heading Accession and Version

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