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scav-2 SCAVenger receptor (CD36 family) related [ Caenorhabditis elegans ]

Gene ID: 176787, updated on 4-Jan-2025

Summary

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Official Symbol
scav-2
Official Full Name
SCAVenger receptor (CD36 family) related
Primary source
WormBase:WBGene00013578
Locus tag
CELE_Y76A2B.6
See related
AllianceGenome:WB:WBGene00013578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be active in membrane. Is expressed in reproductive system. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; progressive myoclonus epilepsy 4; and pulmonary tuberculosis. Orthologous to several human genes including SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See scav-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (13550601..13555334, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial Neighboring gene F-box associated domain-containing protein Neighboring gene Fructose-bisphosphate aldolase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. Means TK, et al. J Exp Med, 2009 Mar 16. PMID 19237602, Free PMC Article
  2. SCAV-3 affects apoptotic cell degradation in Caenorhabditis elegans. Ma A, et al. FEBS Open Bio, 2023 May. PMID 36947094, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SCAVenger receptor (CD36 family) related
NP_499802.3
  • Confirmed by transcript evidence;
    Product from WormBase gene class scav

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13550601..13555334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067401.7 → NP_499802.3  SCAVenger receptor (CD36 family) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499802.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBM7
    Conserved Domains (1) summary
    pfam01130
    Location:46 → 505
    CD36; CD36 family
Nucleotide Protein
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