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F45G2.8 Mitochondrial import inner membrane translocase subunit tim-16 [ Caenorhabditis elegans ]

Gene ID: 176769, updated on 9-Dec-2024

Summary

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Official Symbol
F45G2.8
Official Full Name
Mitochondrial import inner membrane translocase subunit tim-16
Primary source
WormBase:WBGene00009734
Locus tag
CELE_F45G2.8
See related
AllianceGenome:WB:WBGene00009734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Megarbane-Dagher-Melike type. Orthologous to human PAM16 (presequence translocase associated motor 16). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F45G2.8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (13434861..13435670, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TNF Receptor Associated Factor (TRAF) homolog Neighboring gene COMM domain-containing protein Neighboring gene rRNA methyltransferase 2, mitochondrial Neighboring gene MIP18 family protein F45G2.10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Arabidopsis mutant resistant to thaxtomin A, a cellulose synthesis inhibitor from Streptomyces species. Scheible WR, et al. Plant Cell, 2003 Aug. PMID 12897252, Free PMC Article
  2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial import inner membrane translocase subunit tim-16
NP_499775.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13434861..13435670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067374.6 → NP_499775.1  Mitochondrial import inner membrane translocase subunit tim-16 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62250
    Conserved Domains (1) summary
    pfam03656
    Location:1 → 135
    Pam16; Pam16
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62250.1

Gene LinkOut

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