myo-6 Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: myo-6
Official Full Name: Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein
Primary source: WormBase:WBGene00009730
Locus tag: CELE_F45G2.2
See related: AllianceGenome:WB:WBGene00009730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH13 (myosin heavy chain 13); and MYH15 (myosin heavy chain 15). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membraneless organelle	IEA Inferred from Electronic Annotation more info
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info

Preferred Names: Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein

NP_001022590.1

NP_001379434.1

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The following sections contain reference sequences that belong to a specific genome build. Explain