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epg-3 Ectopic P granules protein 3;Transmembrane protein 49 [ Caenorhabditis elegans ]

Gene ID: 176712, updated on 9-Dec-2024

Summary

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Official Symbol
epg-3
Official Full Name
Ectopic P granules protein 3;Transmembrane protein 49
Primary source
WormBase:WBGene00012559
Locus tag
CELE_Y37D8A.22
See related
AllianceGenome:WB:WBGene00012559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in macroautophagy and negative regulation of autophagosome assembly. Located in cytoplasm. Is expressed in body wall musculature; intestine; and pharynx. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See epg-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (12934717..12942288)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein uS10m Neighboring gene RRM domain-containing protein Neighboring gene Secreted protein Neighboring gene Glutamate decarboxylase;Glutamate decarboxylase 1 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Four metazoan autophagy genes regulate cargo recognition, autophagosome formation and autolysosomal degradation. Tian Y, et al. Autophagy, 2010 Oct. PMID 20814246
  2. C. elegans screen identifies autophagy genes specific to multicellular organisms. Tian Y, et al. Cell, 2010 Jun 11. PMID 20550938
  3. The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39. Manil-Ségalen M, et al. Dev Cell, 2014 Jan 13. PMID 24374177
  4. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Swords SB, et al. Autophagy, 2024 Apr. PMID 37942902, Free PMC Article
  5. Nuclear hormone receptor NHR-49 acts in parallel with HIF-1 to promote hypoxia adaptation in Caenorhabditis elegans. Doering KRS, et al. Elife, 2022 Mar 14. PMID 35285794, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ectopic P granules protein 3;Transmembrane protein 49
NP_001360486.1
  • Confirmed by transcript evidence
NP_001360487.1
  • Confirmed by transcript evidence
NP_001360488.1
  • Confirmed by transcript evidence
NP_499688.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12934717..12942288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372669.3 → NP_001360486.1  Transmembrane protein 49 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WWI5
    Conserved Domains (1) summary
    cl00429
    Location:257 → 313
    VTT; VMP1, TMEM41, and TVP38 (VTT) domain

  2. NM_067287.6 → NP_499688.2  Ectopic P granules protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499688.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XWU8
    Conserved Domains (1) summary
    cl00429
    Location:257 → 313
    SNARE_assoc; SNARE associated Golgi protein

  3. NM_001372671.1 → NP_001360487.1  Ectopic P granules protein 3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WXI6
    Conserved Domains (1) summary
    cl00429
    Location:220 → 276
    VTT; VMP1, TMEM41, and TVP38 (VTT) domain

  4. NM_001372670.2 → NP_001360488.1  Ectopic P granules protein 3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WTI5
    Conserved Domains (1) summary
    cl00429
    Location:220 → 276
    VTT; VMP1, TMEM41, and TVP38 (VTT) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XWU8.2

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