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cox-5A Cytochrome c oxidase subunit 5A, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176707, updated on 2-Nov-2024

Summary

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Official Symbol
cox-5A
Official Full Name
Cytochrome c oxidase subunit 5A, mitochondrial
Primary source
WormBase:WBGene00012553
Locus tag
CELE_Y37D8A.14
See related
AllianceGenome:WB:WBGene00012553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cox-5A in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (12905491..12906619)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ENhancer of Uncoordination Neighboring gene Disintegrin and metalloproteinase domain-containing protein unc-71 Neighboring gene Uncharacterized protein Neighboring gene KHEYLRF-amide 4 Neighboring gene MARVEL domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complex I function is defective in complex IV-deficient Caenorhabditis elegans. Suthammarak W, et al. J Biol Chem, 2009 Mar 6. PMID 19074434, Free PMC Article
  2. Genes that may modulate longevity in C. elegans in both dauer larvae and long-lived daf-2 adults. Ruzanov P, et al. Exp Gerontol, 2007 Aug. PMID 17543485, Free PMC Article
  3. Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Zuryn S, et al. Toxicol Sci, 2008 Mar. PMID 17998274
  4. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
  5. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cytochrome c oxidase subunit 5A, mitochondrial
NP_499681.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12905491..12906619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067280.8 → NP_499681.1  Cytochrome c oxidase subunit 5A, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55954, Q9XWV8
    Conserved Domains (1) summary
    cd00923
    Location:37 → 142
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55954.2

Gene LinkOut

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