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hut-1 UAA transporter [ Caenorhabditis elegans ]

Gene ID: 176690, updated on 4-Jan-2025

Summary

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Official Symbol
hut-1
Official Full Name
UAA transporter
Primary source
WormBase:WBGene00013740
Locus tag
CELE_Y111B2A.20
See related
AllianceGenome:WB:WBGene00013740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable UDP-galactose transmembrane transporter activity and UDP-glucose transmembrane transporter activity. Involved in endoplasmic reticulum organization and nematode larval development. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in coelomocyte; egg-laying apparatus; gonad; intestine; and pharyngeal cell. Orthologous to human SLC35B1 (solute carrier family 35 member B1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hut-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (12711560..12713874)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene C2 domain-containing protein Neighboring gene Helicase ssl-1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. Dejima K, et al. FASEB J, 2009 Jul. PMID 19270184, Free PMC Article
  2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate important roles for hut-1 (Y111B2A.20)in development and maintenance of endoplasmic reticulum homeostasis in C. elegans
    Title: The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables UDP-galactose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in UDP-galactose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UAA transporter
NP_001293604.1
  • Confirmed by transcript evidence
NP_499652.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12711560..12713874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067251.5 → NP_499652.1  UAA transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BHL2
    Conserved Domains (2) summary
    pfam08449
    Location:24 → 314
    UAA; UAA transporter family
    cl23754
    Location:177 → 314
    EamA; EamA-like transporter family

  2. NM_001306675.1 → NP_001293604.1  UAA transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293604.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLL6
Nucleotide Protein
Heading Accession and Version

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