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elpc-2 Elongator complex protein 2 [ Caenorhabditis elegans ]

Gene ID: 176687, updated on 2-Nov-2024

Summary

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Official Symbol
elpc-2
Official Full Name
Elongator complex protein 2
Primary source
WormBase:WBGene00013738
Locus tag
CELE_Y111B2A.17
See related
AllianceGenome:WB:WBGene00013738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in tRNA wobble uridine modification. Predicted to be located in cytoplasm and nucleus. Predicted to be part of elongator holoenzyme complex. Is expressed in several structures, including body wall musculature; coelomocyte; excretory cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 58. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See elpc-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (12673677..12686225)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine sulfotransferase A Neighboring gene TAFII55 protein conserved region domain-containing protein Neighboring gene putative splicing factor, arginine/serine-rich 3 Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan. Kawamura K, et al. G3 (Bethesda), 2019 Aug 8. PMID 31213517, Free PMC Article
  2. Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans. Fernandes De Abreu DA, et al. Front Cell Dev Biol, 2020. PMID 33195203, Free PMC Article
  3. Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Kim S, et al. Genetics, 2010 Aug. PMID 20479142, Free PMC Article
  4. Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans. Kawamura K, et al. Aging (Albany NY), 2020 Dec 3. PMID 33276344, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Elongator complex protein 2
NP_499648.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12673677..12686225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067247.11 → NP_499648.3  Elongator complex protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499648.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NEW7
    Conserved Domains (3) summary
    COG2319
    Location:46 → 494
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:565 → 606
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:158 → 425
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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