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glrx-5 Glutaredoxin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176662, updated on 4-Jan-2025

Summary

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Official Symbol
glrx-5
Official Full Name
Glutaredoxin domain-containing protein
Primary source
WormBase:WBGene00013029
Locus tag
CELE_Y49E10.2
See related
AllianceGenome:WB:WBGene00013029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable iron-sulfur cluster binding activity and metal ion binding activity. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See glrx-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (12372582..12373857, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF221-domain-containing protein Neighboring gene Histone H3.3 type 2 Neighboring gene ncRNA Neighboring gene 26S proteasome regulatory subunit 8 Neighboring gene Serine/threonine-protein phosphatase 4 catalytic subunit 2 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Redox properties and evolution of human glutaredoxins. Sagemark J, et al. Proteins, 2007 Sep 1. PMID 17546662
  2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glutaredoxin domain-containing protein
NP_499610.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12372582..12373857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067209.10 → NP_499610.1  Glutaredoxin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499610.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTU9
    Conserved Domains (1) summary
    cd03028
    Location:38 → 126
    GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
Nucleotide Protein
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