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maa-1 ACB domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176612, updated on 9-Dec-2024

Summary

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Official Symbol
maa-1
Official Full Name
ACB domain-containing protein
Primary source
WormBase:WBGene00007680
Locus tag
CELE_C18D11.2
See related
AllianceGenome:WB:WBGene00007680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables fatty-acyl-CoA binding activity. Involved in endocytic recycling and endosome organization. Located in apical part of cell; basal part of cell; and bounding membrane of organelle. Is expressed in hypodermis and intestine. Orthologous to human ACBD4 (acyl-CoA binding domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See maa-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (11819746..11822526, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Glycine rich superfamily member Neighboring gene Uncharacterized protein Neighboring gene Fcf2 domain-containing protein Neighboring gene RNA-binding protein;RRM domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA-binding protein MAA-1. Shamalnasab M, et al. Aging (Albany NY), 2017 Jul 27. PMID 28758895, Free PMC Article
  2. MAA-1, a novel acyl-CoA-binding protein involved in endosomal vesicle transport in Caenorhabditis elegans. Larsen MK, et al. Mol Biol Cell, 2006 Oct. PMID 16870706, Free PMC Article
  3. Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency in Caenorhabditis elegans. Lee W, et al. Proteomics, 2006 Feb. PMID 16404716
  4. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organismal reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ACB domain-containing protein
NP_499531.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11819746..11822526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067130.6 → NP_499531.1  ACB domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499531.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTZ5
    Conserved Domains (1) summary
    pfam00887
    Location:3 → 84
    ACBP; Acyl CoA binding protein
Nucleotide Protein
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