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such-1 Suppressor of spindle checkpoint defect 1 [ Caenorhabditis elegans ]

Gene ID: 176583, updated on 2-Nov-2024

Summary

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Official Symbol
such-1
Official Full Name
Suppressor of spindle checkpoint defect 1
Primary source
WormBase:WBGene00013443
Locus tag
CELE_Y66D12A.17
See related
AllianceGenome:WB:WBGene00013443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Is expressed in germ line; head neurons; sperm; and vulval precursor cell. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See such-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (11512862..11523759, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase spe-6 Neighboring gene ArgoN domain-containing protein Neighboring gene DUF1604 domain-containing protein;SMAP domain-containing protein;Spen family transcriptional repressor Neighboring gene General transcription and DNA repair factor IIH helicase/translocase subunit XPB Neighboring gene Carrier domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans. Tarailo M, et al. Genetics, 2007 Apr. PMID 17237515, Free PMC Article
  2. Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis. Stein KK, et al. Genetics, 2010 Dec. PMID 20944012, Free PMC Article
  3. Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans. Bezler A, et al. Genetics, 2010 Dec. PMID 20944014, Free PMC Article
  4. A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Green RA, et al. Cell, 2011 Apr 29. PMID 21529718, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Suppressor of spindle checkpoint defect 1
NP_499485.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11512862..11523759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067084.7 → NP_499485.2  Suppressor of spindle checkpoint defect 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499485.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Q00
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95Q00.2

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