smc-3 Structural maintenance of chromosomes protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: smc-3
Official Full Name: Structural maintenance of chromosomes protein 3
Primary source: WormBase:WBGene00004873
Locus tag: CELE_Y47D3A.26
See related: AllianceGenome:WB:WBGene00004873
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable double-stranded DNA binding activity. Predicted to be involved in mitotic sister chromatid cohesion. Located in chromatin. Part of cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Orthologous to human SMC3 (structural maintenance of chromosomes 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See smc-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 19

Sequence:: Chromosome: III; NC_003281.10 (11290904..11306247)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a new temperature-sensitive mutation in the using Caenorhabditis elegans SMC-3 protein to study the role of cohesin in the repair of DNA double-strand breaks (DSBs) and hence in meiotic crossing over
Title: A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y47D3A.aa (e-PCR)
- UniSTS:323678

Y47D3A.z (e-PCR)
- UniSTS:323684

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of cohesin complex	IDA Inferred from Direct Assay more info	PubMed
part_of cohesin complex	IPI Inferred from Physical Interaction more info	PubMed
part_of mitotic cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Structural maintenance of chromosomes protein 3

NP_001255118.1

Confirmed by transcript evidence

NP_001255119.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11290904..11306247

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268189.4 → NP_001255118.1 Structural maintenance of chromosomes protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255118.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2FDA8, I2HAB3, Q9U2C1

Conserved Domains (4) summary

cd03272
Location:3 → 151

ABC_SMC3_euk; ATP-binding cassette domain of eukaryotic SMC3 proteins

smart00968
Location:534 → 646

SMC_hinge; SMC proteins Flexible Hinge Domain

COG1196
Location:1 → 1198

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl21455
Location:1093 → 1187

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001268190.3 → NP_001255119.1 Structural maintenance of chromosomes protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255119.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2FDA8

Conserved Domains (1) summary

cl21455
Location:217 → 311

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases