umps-1 Orotidine 5'-phosphate decarboxylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: umps-1
Official Full Name: Orotidine 5'-phosphate decarboxylase
Primary source: WormBase:WBGene00011559
Locus tag: CELE_T07C4.1
See related: AllianceGenome:WB:WBGene00011559
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in several processes, including UMP biosynthetic process; determination of adult lifespan; and positive regulation of brood size. Located in cytoplasm. Is expressed in head; intestine; neurons; and tail. Used to study orotic aciduria. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See umps-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (10355837..10357648, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the conserved uridine monophosphate phosphoribosyltransferase (UMPS), which acts in pyrimidine biosynthesis, is required for NAD(+) biosynthesis in place of the missing QPRTase
Title: Uridine monophosphate synthetase enables eukaryotic de novo NAD(+) biosynthesis from quinolinic acid.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T07C4.1 (e-PCR)
- UniSTS:306636

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotate phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables orotate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotidine-5'-phosphate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotidine-5'-phosphate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables orotidine-5'-phosphate decarboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UMP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleobase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV-C	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Orotidine 5'-phosphate decarboxylase

NP_499291.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10355837..10357648 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066890.6 → NP_499291.1 Orotidine 5'-phosphate decarboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499291.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDZ2

Conserved Domains (2) summary

COG0461
Location:12 → 212

PyrE; Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]

pfam00215
Location:264 → 482

OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family