vglu-2 Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: vglu-2
Official Full Name: Major facilitator superfamily (MFS) profile domain-containing protein
Primary source: WormBase:WBGene00010755
Locus tag: CELE_K10G9.1
See related: AllianceGenome:WB:WBGene00010755
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable L-glutamate transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Predicted to be involved in glutamatergic synaptic transmission; neurotransmitter loading into synaptic vesicle; and regulation of synapse structure or activity. Predicted to be located in membrane. Predicted to be active in excitatory synapse and synaptic vesicle membrane. Is expressed in AIA; hypodermis; uterine epithelial cell; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A6 (solute carrier family 17 member 6); SLC17A7 (solute carrier family 17 member 7); and SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synapse structure or activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in excitatory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

Preferred Names: Major facilitator superfamily (MFS) profile domain-containing protein

NP_499276.1

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The following sections contain reference sequences that belong to a specific genome build. Explain