U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

vps-29 Vacuolar protein sorting-associated protein 29 [ Caenorhabditis elegans ]

Gene ID: 176424, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
vps-29
Official Full Name
Vacuolar protein sorting-associated protein 29
Primary source
WormBase:WBGene00014234
Locus tag
CELE_ZK1128.8
See related
AllianceGenome:WB:WBGene00014234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Located in cytosol. Orthologous to human VPS29 (VPS29 retromer complex component). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See vps-29 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (10111953..10113058, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Serpentine receptor class T-55 Neighboring gene Uncharacterized protein Neighboring gene Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial Neighboring gene U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants. Lorenowicz MJ, et al. Cell Signal, 2014 Jan. PMID 24056045
  2. Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments. Oikonomou G, et al. Dev Biol, 2012 Feb 1. PMID 22138055, Free PMC Article
  3. Protein kinase CK2 is required for Wntless internalization and Wnt secretion. de Groot RE, et al. Cell Signal, 2014 Dec. PMID 25178265
  4. RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. Cruciat CM, et al. Science, 2013 Mar 22. PMID 23413191
  5. SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. McGough IJ, et al. Nat Commun, 2018 Sep 13. PMID 30213940, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Vacuolar protein sorting-associated protein 29
NP_001022987.1
  • Confirmed by transcript evidence
NP_001022988.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10111953..10113058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027817.4 → NP_001022988.1  Vacuolar protein sorting-associated protein 29 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022988.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86D99
    Conserved Domains (1) summary
    cd07394
    Location:6 → 185
    MPP_Vps29; Homo sapiens Vps29 and related proteins, metallophosphatase domain

  2. NM_001027816.4 → NP_001022987.1  Vacuolar protein sorting-associated protein 29 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022987.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVX5
    Conserved Domains (1) summary
    cd07394
    Location:2 → 181
    MPP_Vps29; Homo sapiens Vps29 and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.