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rgs-1 RGS domain-containing protein;Regulator of G-protein signaling rgs-1 [ Caenorhabditis elegans ]

Gene ID: 176415, updated on 9-Dec-2024

Summary

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Official Symbol
rgs-1
Official Full Name
RGS domain-containing protein;Regulator of G-protein signaling rgs-1
Primary source
WormBase:WBGene00004344
Locus tag
CELE_C05B5.7
See related
AllianceGenome:WB:WBGene00004344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activator activity. Involved in chemosensory behavior and sensory perception of bitter taste. Is expressed in several structures, including excretory cell; head; nervous system; tail; and vulval muscle. Orthologous to several human genes including RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rgs-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (10014188..10016558, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene XK-related protein Neighboring gene ncRNA Neighboring gene putative insulin-like peptide alpha-type 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulator of G protein signaling-1 modulates paraquat-induced oxidative stress and longevity via the insulin like signaling pathway in Caenorhabditis elegans. Wu M, et al. Toxicol Lett, 2017 May 5. PMID 28366735
  2. An N-terminal region of Caenorhabditis elegans RGS proteins EGL-10 and EAT-16 directs inhibition of G(alpha)o versus G(alpha)q signaling. Patikoglou GA, et al. J Biol Chem, 2002 Dec 6. PMID 12354761
  3. Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep. Huang H, et al. G3 (Bethesda), 2017 Sep 7. PMID 28743807, Free PMC Article
  4. The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity. Krzyzanowski MC, et al. PLoS Genet, 2013. PMID 23874221, Free PMC Article
  5. G-protein signaling: satisfying the basic necessities of life. Wilkie TM. Curr Biol, 2000 Nov 30. PMID 11114530

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of bitter taste IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
RGS domain-containing protein;Regulator of G-protein signaling rgs-1
NP_001255056.1
  • Confirmed by transcript evidence
NP_001369842.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10014188..10016558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382973.1 → NP_001369842.1  Regulator of G-protein signaling rgs-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34295, Q9NHP9
    Conserved Domains (1) summary
    cl02565
    Location:38 → 154
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_001268127.3 → NP_001255056.1  RGS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1MN65
    Conserved Domains (1) summary
    cl02565
    Location:38 → 154
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34295.3

Gene LinkOut

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