vha-1 V-type proton ATPase 16 kDa proteolipid subunit c 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vha-1
Official Full Name: V-type proton ATPase 16 kDa proteolipid subunit c 1
Primary source: WormBase:WBGene00006910
Locus tag: CELE_R10E11.8
See related: AllianceGenome:WB:WBGene00006910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including lysosomal lumen acidification; ovulation; and regulation of syncytium formation by plasma membrane fusion. Located in membrane raft. Is expressed in excretory cell; intestine; and rectum. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vha-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_003281.10 (9781254..9781763)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A new function for V0-ATPase in apical trafficking and epithelial polarity maintenance and the promising use of the C. elegans intestine as an in vivo model to better understand the molecular mechanisms of rare genetic enteropathies.
Title: A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R10E11.8 (e-PCR)
- UniSTS:321026

R10E11.4 (e-PCR)
- UniSTS:306071

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosomal lumen acidification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of syncytium formation by plasma membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of syncytium formation by plasma membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	HDA more info	PubMed
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of proton-transporting two-sector ATPase complex, proton-transporting domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: V-type proton ATPase 16 kDa proteolipid subunit c 1

NP_499165.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9781254..9781763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066764.7 → NP_499165.1 V-type proton ATPase 16 kDa proteolipid subunit c 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499165.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21898

Conserved Domains (2) summary

pfam00137
Location:107 → 166

ATP-synt_C; ATP synthase subunit C

cl00466
Location:24 → 132

ATP-synt_C; ATP synthase subunit C