hlh-11 Helix-loop-helix protein 11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hlh-11
Official Full Name: Helix-loop-helix protein 11
Primary source: WormBase:WBGene00001955
Locus tag: CELE_F58A4.7
See related: AllianceGenome:WB:WBGene00001955
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including excretory cell; intestine; male-specific anatomical entity; non-striated muscle; and somatic nervous system. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hlh-11 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (9622147..9626528)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HLH-11 modulates lipid metabolism in response to nutrient availability.
Title: HLH-11 modulates lipid metabolism in response to nutrient availability.
hlh-11 may function to regulate serotonin-mediated egg laying at the downstream of tax-6.
Title: Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58A4.7 (e-PCR)
- UniSTS:305651

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Helix-loop-helix protein 11

NP_001367058.1

Confirmed by transcript evidence

NP_499129.2

Confirmed by transcript evidence

NP_499130.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9622147..9626528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066728.8 → NP_499129.2 Helix-loop-helix protein 11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499129.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34474, Q7JMU4, Q7YXC9, Q86DA4, Q9U3E1

Conserved Domains (1) summary

pfam00010
Location:113 → 163

HLH; Helix-loop-helix DNA-binding domain
NM_001379865.2 → NP_001367058.1 Helix-loop-helix protein 11 [Caenorhabditis elegans]

Status: REVIEWED
NM_066729.10 → NP_499130.2 Helix-loop-helix protein 11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499130.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34474

Conserved Domains (1) summary

pfam00010
Location:111 → 161

HLH; Helix-loop-helix DNA-binding domain