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vha-14 V-type proton ATPase subunit D [ Caenorhabditis elegans ]

Gene ID: 176338, updated on 4-Jan-2025

Summary

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Official Symbol
vha-14
Official Full Name
V-type proton ATPase subunit D
Primary source
WormBase:WBGene00010130
Locus tag
CELE_F55H2.2
See related
AllianceGenome:WB:WBGene00010130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to contribute to P-type proton-exporting transporter activity. Predicted to be involved in regulation of intracellular pH. Predicted to be part of proton-transporting V-type ATPase complex. Orthologous to human ATP6V1D (ATPase H+ transporting V1 subunit D). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See vha-14 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (9508100..9509757)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase-associated protein CTR9 Neighboring gene Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn] Neighboring gene pseudo Neighboring gene Putative transmembrane ascorbate-dependent reductase CYB561 homolog Neighboring gene Uncharacterized protein Neighboring gene FIP (Fungus-Induced Protein) Related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes. Maheshwari R, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849797, Free PMC Article
  2. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717
  3. Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity. Yu Y, et al. Elife, 2024 Jan 19. PMID 38240316, Free PMC Article
  4. An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development. Miao R, et al. Dev Cell, 2020 Jan 6. PMID 31735670
  5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to P-type proton-exporting transporter activity IC
Inferred by Curator
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting V-type ATPase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit D
NP_499094.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9508100..9509757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066693.7 → NP_499094.1  V-type proton ATPase subunit D [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34462
    Conserved Domains (1) summary
    pfam01813
    Location:19 → 208
    ATP-synt_D; ATP synthase subunit D
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34462.1

Gene LinkOut

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